The proteasome droplets also contain ubiquitin-tagged proteins and multiple interacting proteins, by which induce liquid-liquid phase separation of the proteasome for rapid degradation of unwanted ...

The proteasome, being the final destination for proteins tagged for proteolytic degradation, is intimately associated with the ubiquitination pathway, one which flags proteins with strings of the ...

The ubiquitin proteasome system (UPS) provides a mechanism for clearing damaged proteins from cells, as well as the regulated proteolysis of intracellular proteins. The success of the proteasome ...

Protein turnover is crucial in maintaining cellular homeostasis and this process is largely controlled by the Ubiquitin Proteasome Pathway (UPP). The pathway consists of an enzymatic cascade that ...

Original Article Published: 07 September 2007 MDA-7/IL-24, a novel tumor suppressor/cytokine is ubiquitinated and regulated by the ubiquitin–proteasome system, and inhibition of MDA-7/IL-24 ...

Proteasome inhibitors are drugs that were initially designed to explore the activities of proteasomes. However, once the ubiquitin–proteasome pathway was discovered, the potential effects of ...

Polyubiquitination targets proteins for recognition and processing by the 26S proteasome, a cylindrical organelle that recognizes ubiquitinated proteins, degrades the proteins, and recycles ubiquitin.

However, sometimes the proteasome breaks down proteins without the help of ubiquitin tags, pointing to the existence of another, ubiquitin-independent mechanism of protein degradation.

The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins.

The big biotech firm Celgene will work with San Francisco-based Nurix to develop small molecules that function through the ubiquitin-proteasome system (UPS) to modulate protein homeostatis.