The ubiquitin-dependent proteasome phase separation may be linked to clearance of aggregates that causes neurodegenerative diseases. These results were published in Nature. Advanced Search ...

The 26S proteasome constitutes the central proteolytic machinery of the highly conserved ubiquitin/proteasome system, the cell’s major tool for extralysosomal protein degradation. Recently, a ...

The proteasome, that large subcellular grinder that recycles protein, plays a major role in localized degeneration of axons, ... Involvement of the ubiquitin-proteasome system in the early stages of ...

Success as An Anti-Cancer Agent Has Fueled Efforts to Discover Proteasome Inhibitors That Raise Proteins Levels with Beneficial Effects The ubiquitin proteasome system (UPS) provides a mechanism ...

The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins. As the maintenance of protein homeostasis is essential ...

A major pathway for protein degradation is initiated by the addition of multiple 76–amino acid ubiquitin monomers via a three-step process of ubiquitin activation and substrate recognition.

Proteasome inhibitors are drugs that were initially designed to explore the activities of proteasomes. However, once the ubiquitin–proteasome pathway was discovered, the potential effects of ...

A communications breakdown between two biochemical pathways is involved in causing cataracts in mice, scientists have discovered. The newfound relationship between the ubiquitin and calpain ...

The pathway consists of an enzymatic cascade that links the polypeptide cofactor Ubiquitin to specific protein targets, which mark them for degradation by the proteasome. This cascade is highly ...

Proteasome collaborate with ubiquitin to degrade proteins. [Love Employee/Getty Images] Newly Identified Proteasomal Protein Disposal Mechanism Bypasses Ubiquitin Tagging. August 24, 2023.

Critical cellular processes are regulated, in part, by maintaining the appropriate intracellular levels of proteins. Whereas de novo protein synthesis is a comparatively slow process, proteins are ...