They can also appear spontaneously during the replication of DNA. Mutations generally fall into two types: point mutations and chromosomal aberrations. In point mutations, one base pair is changed.

Base substitutions are the simplest type of gene-level mutation, and they involve the swapping of one nucleotide for another during DNA replication. For example, during replication, a thymine ...

the findings represent a step forward in understanding the vast diversity of these types of cancers and highlight the importance of analyzing the cellular "state" prior to mutation. To perform ...