Given the importance of CNP in angiogenesis, researchers reasoned ... Corp. "It is a successful approach to target the immunosuppressive tumor microenvironment, which should lead to a breakthrough ...

In tumor microenvironments, substances like 8-OHG drive macrophage polarization towards the immunosuppressive M2 type. M1 macrophages, with higher ferritin expression, are more resistant to ...

In this essay, published in 1980, Nathan Kaliss describes the experiments that opened the door to developing immunosuppressants for organ transplant and cancer immunotherapy. Kaliss described the ...

or perhaps by the time the tumor has broken through the basement membrane (as pictured above), angiogenesis takes place. Angiogenesis is the recruitment of blood vessels from the network of ...

“Superkines have a very high affinity for specific receptor subtypes to either selectively activate tumor-killing immune cells or block immunosuppressive cells of the tumor microenvironment ...

The immunosuppression induced by tumor-associated macrophages (TAMs) may be pivotal in this process. TAMs have been shown to impede immune system function, thereby fostering tumor growth and ...

We also are exploring therapeutic options to block fatty acid accumulation and immunosuppressive signals between the cancer cells and the neutrophils,” said Zhang, William T. Butler, M.D ...

Determining the effects of drugs on DCs, which are the main players in induction of immunity, and MDSCs and Treg cells, which might be critical effectors in the tumor-induced immunosuppressive ...

Therefore, the current research team set out to identify how glioblastoma reprograms tumor-infiltrating neutrophils to become immunosuppressive. The researchers investigated a subset of neutrophils ...

Compass Therapeutics, Inc. (Nasdaq: CMPX), a clinical-stage, oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics to treat multiple human diseases, today ...

These include modulation of the microvasculature via angiogenesis-targeted ... on effector cells in the tumor microenvironment, and alleviation of immunosuppressive mechanisms used by tumors ...