The Transformers: Generation 2 comic book introduced a "second ... and conquer all who were in their way. This forced Optimus Prime and Megatron's forces to unite against the common threat ...

The first two of these are based on Optimus Prime and Megatron from the anime series Transformers ... Generation 2, the various anime and Beast Wars being some of the timelines represented.

Blizzard Entertainment has revealed an Overwatch 2 x Transformers crossover event ... transforming Reinhardt into Optimus Prime, Ramattra into Megatron, Illari into Arcee and Bastion into Bumblebee.