In mouse model experiments, increasing FGF21 preserved both the size and function of the thymus, allowing for greater T-cell variation. Inside the labyrinth: How thymic structures rebuild Stromal ...

In thymic epithelial cells, the research team upregulated a transcription factor called Forkhead box N1 (FOXN1), which had previously been implicated in age-related thymus shrinkage. Consequently, the ...

The wide adoption of genetic engineering techniques in the late 1990’s played an important role in demonstrating the complexity and importance of communication between stromal cells and immune ...