As the thymus ages, the walls of these structures collapse. Upon thymic regrowth, the walls are rebuilt. Experiments in mouse models showed that an increase in FGF21 could delay thymic atrophy.

Founded in 2001, ThymUS brings together international researchers working on thymus and T-cell biology. The abstract entitled “A rapid and scalable thymus organoid development method for ...

An animated 3D maximum projection through 60 µm of thymus tissue (related to Fig. 8d) from a representative FoxN1Cre R26Confetti LPOFGF21 mouse at 6 months of age. Blue, CFP; yellow, YFP; red, RFP.