The thymus functions as the primary lymphoid organ responsible for the generation of T cells and plays a crucial role in preventing autoimmune reactions by eliminating autoreactive cells before ...

The thymus is a crucial training ground for T-cells, the body's "white knights," where they learn to battle the various ...

The epithelial cells, known as TECs (thymic epithelial cells), are further classified into cTECs (cortical TECs) and mTECs (medulla TECs). Thymic organogenesis is governed by the highly potent ...

The thymus and T cells. T cells are white blood cells. ... These are both known as thymic epithelial tumors (TETs). Thymomas are slower-growing tumors that don't often spread beyond your thymus.

Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus. Developmental Cell , 2023; DOI: 10.1016/j.devcel.2023.08.017 Cite ...

Thymic epithelial cells (TECs) have an indispensable role in these processes, and previous studies have shown the notable heterogeneity of these cells. Here, using multi-omic analysis, ...

Non-functional clusters of thymic epithelial cell (TECs) emerge in the thymus with age. On the left, the thymus from a two-month-old mouse has few age-associated TECs (in blue). On the right, the ...

The team genetically engineered mice to have the GTF2I L424H mutation in thymic epithelial cells and found abnormal development of the cells in young animals. As the animals age, they develop ...

Researchers discovered two unusual changes within thymic epithelial cell (TEC) states. The TECs are age-associated and form clusters of thymic cells. ... Unfortunately, these age-associated TECs do ...

Before T cells leave the thymus to fight infections, ... Transcriptomic diversity in human medullary thymic epithelial cells, Nature Communications (2022). DOI: 10.1038/s41467-022-31750-1.

Research identifies two states of age-associated thymic epithelial cells, linking thymic degeneration to aging and injury, impacting immune system function. AZoLifeSciences.

Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus. Developmental Cell . 10.1016/j.devcel.2023.08.017.