In the liver, TGF-β signaling is involved in maintaining liver homeostasis and responding to injury by modulating inflammation and fibrosis. HIPPO pathway: The HIPPO pathway is a kinase cascade ...

These processes are regulated by the cytokines TGF ... connective tissue growth factor (CTGF) in serum might provide information on fibrogenic activity. The extension of pathogenetic concepts of ...

Many newly described signaling pathway proteins may be important ... on the effects of other possible markers of fibrosis, such as serum CTGF and TGF-β. Randomized, controlled trials of ...

Programs address the need for disease-modifying therapies targeting root causes of fibrosis Funding will support ... other CCN family members, including CTGF/CCN2 and WISP1/CCN4, on multiple ...