Several factors that induce fibrosis have been identified ... Figure 1: Interactions between CTGF, EGF, PDGF and the profibrotic TGF-β pathway. The fully humanized monoclonal antibody FG-3019 ...

Some of the major conserved molecular processes involve TGF-β, PDGF, CTGF, vasoactive compounds ... matrix signaling pathways. The fact that tissue fibrosis is remarkably plastic suggests ...

Kidney fibrosis, a common endpoint of chronic kidney disease (CKD), is strongly linked to aging, with cellular senescence ...

"Letrozole ameliorated MCD- and CCl4-induced liver fibrosis by suppressing the Yap-Ctgf pathway by partially modifying the expressions of Hsd17b13 and Cyp26a1, which reduced retinoic acid level in ...

“Letrozole ameliorated MCD- and CCl4-induced liver fibrosis by suppressing the Yap-Ctgf pathway by partially modifying the expressions of Hsd17b13 and Cyp26a1, which reduced retinoic acid level ...

In the liver, TGF-β signaling is involved in maintaining liver homeostasis and responding to injury by modulating inflammation and fibrosis. HIPPO Pathway: The HIPPO pathway is a kinase cascade ...

These processes are regulated by the cytokines TGF ... connective tissue growth factor (CTGF) in serum might provide information on fibrogenic activity. The extension of pathogenetic concepts of ...

PMD include various oral mucosal diseases such as leukoplakia, erythroplakia, oral submucous fibrosis (OSMF), oral lichen ... mechanism involved in EMT by cross-talk between TGF-β and Wnt/β-catenin ...

Dysfunctional TGF-Beta is a major contributor to lung diseases and contributes to inflammation in pulmonary fibrosis that leads ... for targets in the Wnt pathway, a key signaling pathway that ...

This study aimed to elucidate the regulation of NAFLD-related liver fibrosis induced by HO-1 through the SIRT1/TGF-ß/Smad3 pathway. HO-1 induction and inhibition were established in C57BL/6J mice ...

More information: Frederik Link et al, ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation, Gut (2024). DOI: 10.1136/gutjnl-2024-333213 ...