Negative selection in fetal thymus clonally deletes many self-reactive T cells, permanently removing them as potential sources of autoimmune attack. Self-reactive T cells slipping past thymic ...

The thymus selects and educates immature T-cells, turning only the best candidates ... I will be keen to discuss strategic patient selection by HLA matching. I will be able to say more about ...

Pre-T cell levels were low in marrow of neonatally thymectomized mice and could be restored to control values by treatment in vivo with an extract of mouse thymus. Levels of activity were also low in ...

T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to ...

"We found that part of the weaker response is due to negative selection—a process that eliminates overly reactive T cells in the thymus—as well as a more significant factor: two proteins (PD-1 ...