Scientists from the Cancer Dependency Map (DepMap) at the Broad Institute of MIT and Harvard and Columbia University have ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

Researchers from Tango Therapeutics Inc. have unveiled DNA ligase 1 (LIG1) as a potential new therapeutic target for synthetic lethality in BRCA1-mutant cancers after CRISPR/Cas9 screening.

ACB’s expertise in synthetic lethal approaches to precision oncology, MYC biology and cancer cell biology has enabled it to build a broad pipeline. Rather than focus on a single asset or one ...

RNAi as a tool for functional genomics & identification of synthetic lethal interactions RNAi is the mechanism whereby introduction of dsRNA into a cell results in the degradation of a mRNA ...

"It is our great pleasure to share with you the successful approval of Senaparib for the Chinese market, which is another strong proof of the excellence of IMPACT's in-house synthetic lethality R ...

Tumor development is an evolutionary process driven by an accumulation of mutations allowing cells to acquire traits that can ultimately lead to a cancerous state. [1] As a consequence cancer is ...