In the Season 14 premiere of Supernatural, Jensen Ackles is possessed by Michael and doesn't appear as Dean Winchester.

It's quite difficult to imagine an episode of Supernatural without the main protagonists, Dean and Sam Winchester.

Supernatural, an American television series that aired for 15 seasons (327 episodes) from 2005 to 2020, was developed by Eric Kripke.

Supernatural was a big ... and over the course of one 22-episode season, the show explored many of the adventures of Sam and Dean Winchester from seasons 1 and 2 of the live-action series.