Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.

Although the upregulation of the Notch signalling pathway is a deterministic factor in BAVM, the mechanism by which this pathway is upregulated in patients with BAVM is uncertain. The effects of serum ...

By assessing gene expression changes in endothelial cells, the team found that AHR-deficient mice showed disruption of the apelin signaling pathway, which is involved in vessel function regulation.

Stimulation of endothelial cells with ephrin-B2 in the absence of VEGF-C triggers VEGFR-3 internalization but cannot activate signaling, indicating functional cooperation between both pathways.

LMU researchers identify a crucial signaling pathway—with therapeutic potential ... RNA sequencing and 3D microscopy revealed ...