In this long-term work, the researchers demonstrated that the NOTCH signaling pathway, conserved throughout the evolution of all multicellular organisms, plays an essential role in the ...

Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.

which includes cellular signaling pathways and downstream targets, cell differentiation and organismal development, responses to cell stress and nutritional requirements, and programmed cell death.