Newborn infants have little or no secretory IgA (SIgA) at birth. Earlier studies suggest that premature infants do not significantly differ from term babies in their rate of acquisition of SIgA.

First, antibodies (i.e., secretory IgA) in the mucosa neutralize S ... impede proper humoral response (antibody generation) to the bacteria and also deplete certain subtypes of T-cells (via ...

More information: Merel van Gogh et al, Next-generation IgA-SEQ allows for high-throughput, anaerobic, and metagenomic assessment of IgA-coated bacteria, Microbiome (2024). DOI: 10.1186/s40168-024 ...

[16] Breast milk contains high concentration of secretory antibodies, mainly IgA, with a broad range of specificities reflecting both maternal immunologic memory and antigenic stimulation of ...

Upper respiratory tract infection (URTI) is a common illness. Recent studies have shown that suppression of secretory immunoglobulin A (SIgA) is associated with increased incidence of URTI. Objective: ...