Ribosomal subunit assembly and biogenesis constitute a fundamental process vital for cellular protein synthesis across all domains of life. This complex, multi-step pathway involves the ...

Approximately 30% of the nucleolar proteome consists of proteins involved in ribosome biogenesis, marking the nucleolus as the central location for ribosome assembly (Boisvert et al., 2007).

The yellow cells, indicated by arrows, are the first evidence of increased ribosome biogenesis in cells during epithelial-to-mesenchymal transition (EMT). [Vincent et al.] Researchers from Uppsala ...

A somatic ribosomal protein mutation can therefore promote the transformation of cancer but will not be sufficient on its own to cause it. They and mutations in ribosome biogenesis factors can ...

"The relatively compact phenotype of the 90S pre-ribosome gave us the idea that this shell, in combination with other factors, encloses the smaller of the two ribosomal subunits during biogenesis ...

Owing to the enormous complexity of the ribosome, the assembly process employs upwards of 200 non-ribosomal biogenesis factors that function transiently. The first structure that results from pre ...

The process of ribosome biogenesis involves the transcription of rRNA precursors, their processing and modification, and the association with ribosomal proteins to form the mature ribosomal subunits.

Since ribosomal proteins play a crucial role in ribosome biogenesis, these findings prompted scientists to investigate the role of MAR and RPL27A in the regulation of mature rRNA abundance and ...

Their study therefore argues that ribosome biogenesis may be more than just a pro-proliferative process. "Until recently, ribosomes have been considered to play only passive roles during the ...

CX-3543, Cylene's most advanced product for the treatment of multiple cancers, acts as a Ribosomal RNA Biogenesis Inhibitor (RBI) by targeting a Protein:DNA interaction that is amplified in cancer ...