What is regulation, where does it occur on ... provide the great variety of signaling outcomes through ERBB receptors after ligand binding as well as prevent the dangerous state of indefinite ...

The mechanism of how synergistic H-bonds potentiate ligand binding to a receptor is shown. This material relates to a paper that appeared in the March 25, 2016 issue of Science, published by AAAS.

Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid mediators exert their effects by activating two G protein-coupled receptors, ...

These modules allow the ProteinReDiff framework to capture intricate protein–ligand interactions, improve the fidelity of ...