Signal binding to membrane receptor tyrosine kinases (RTKs) activates an enzyme called a kinase. Learn how kinases initiate a signaling cascade that relays information to the nucleus.

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

The team is optimizing the cancer genome analysis system to integrate it into CRC diagnosis and tailor treatments based on ...

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer ...

TIE1, a receptor tyrosine kinase, was found to be upregulated by ... In conclusion, this work has identified a novel signaling pathway involving ING5, TIE1, and PDK1 Y163 phosphorylation that ...

Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and the RAF kinase and MAPK pathways. Over 10,000 patients have ...

Savolitinib blocks atypical activation of the MET receptor tyrosine kinase pathway that occurs because of mutations (such as exon 14 skipping alterations or other point mutations), gene ...

A recent publication in Genes & Diseases has delivered a compelling synthesis of the latest insights into the cellular ...

HUTCHMED (China) Limited (“ HUTCHMED ”) (Nasdaq/AIM:​HCM; HKEX:​13) today announces that it has completed enrollment of the registration phase of its Phase II trial of savolitinib in gastric cancer ...