We incorporated the non-natural photoreactive amino acid p-benzoyl-L-phenylalanine (Bpa) into the RNA polymerase ... of the Pol II central cleft. Mutations in the Rpb2 lobe and protrusion domains ...

While RNA polymerase II was known to be critical in ensuring the accuracy of transcription, it had been a long-standing puzzle as to how this enzyme accomplishes this difficult task. Scientists ...

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...

structure of the RNA-dependent RNA polymerase (RdRp), which is a key part of the virus’s replication machinery that makes copies of its RNA genome (Science 2020 10.1126/science.abb7498).