RNA polymerase II (Pol II) transcribes all eukaryotic protein-coding genes and most non-coding RNA genes. The final step of transcription is termination, which leads to the release of Pol II and ...

A genetic mutation that fuses two genes drives several different cancer types by forming networks of protein interactions that alter gene expression in cells, a study by UT Southwestern Medical Center ...

The nomenclature of different promoter-associated RNA polymerase II (Pol II) species is explicitly defined in an effort to provide consistency in future literature. The known mechanistic features ...

RNA polymerase II 3 transcribes protein-coding genes into messenger RNA (mRNA). This 12-subunit enzyme works as a complex that directly influences gene expression through its production of pre-mRNA ...

While RNA polymerase II was known to be critical in ensuring the accuracy of transcription, it had been a long-standing puzzle as to how this enzyme accomplishes this difficult task. Scientists ...

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...

There are a variety of different types of RNA polymerases that can transcribe different types of RNA. RNA polymerase II, shown here, is responsible for creating messenger RNA (mRNA), which is the main ...

RNAP II is the enzyme primarily responsible for the synthesis of messenger RNA (mRNA). RNAP I and III contain an extra heterodimeric subunit. RNAP III alone has a heterotrimeric subunit ...

This enables the RNA polymerase (RNAP) and the ribosome to coordinate their functions and work together efficiently directly.

Like mRNA, the majority of lncRNAs are polyadenylated and transcribed by RNA polymerase II. Loci that produce lncRNAs have many features similar to protein-coding genes, promoters, alternative ...