Taste, pain, or response to stress—nearly all essential functions in the human body are regulated by molecular switches ...

Solution state NMR will also have a complementary role in post-genomic analysis, particularly considering that (i) many protein targets do not provide crystals suitable for crystallographic analys ...

Researchers try multiple means to get high-quality membrane proteins for X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy studies. As much as 30% of human genes code for ...

Phosphate buffer is an economical non-protonated buffer, and there also are a variety of perdeuterated buffers (d-Tris, d-HEPES) available that do not obscure protein NMR signals. Protein preparation ...

The researchers used nuclear magnetic resonance (NMR) spectroscopy combined with advanced computational methods ...

To capture the ensembles of conformations adopted by disordered proteins, researchers needed a method that was better suited to their twists and turns. Nuclear magnetic resonance (NMR) spectroscopy ...

Dr. Anam Nayab, a US-based Pakistani research scholar has shared her insights on how the study of proteins is crucial for ...

Structure determination by NMR typically requires a protein concentration of 0.5 mM or greater, stable for several days at the desired temperature, usually 20-40 o C. Proteins and peptides should be ...

NMR can identify different nuclei in a molecule and analyze large proteins and other large molecules using three dimensional (3-D) techniques. This instrument provides powerful information for the ...

The new 1.2 GHz NMR complements the existing 800 MHz NMR in Basel and other high-field NMRs for protein structure determination, measurement of protein dynamics, ligand binding studies ...

Scientists at Hyderabad’s Centre for Cellular and Molecular Biology (CCMB) have made a discovery that could change how we ...

My research concentrates on protein structure and function, mainly by means of NMR, and is described in more detail below. I have written two books (The Nuclear Overhauser Effect, with David Neuhaus, ...