Instead of DNA-based systems, the researchers built their decision-making circuit with proteins, de novo protein heterodimers and engineered proteases. By creating protein pairs that bind together ...

Biophysicists have elucidated why unexpected structures can sometimes arise during protein design. Artificially designed proteins are usually based on building blocks that obey strict rules of ...

New findings show that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like ...

Instead, we think this circuit causes the craving of highly rewarding ... Conversely, when the researchers injected a virus engineered to produce a protein that dampens the cells' activity ...