Targeted inhibition of a "signal jammer" protein may improve how tumors respond to immunotherapy. Published today in Nature, ...

Instead of DNA-based systems, the researchers built their decision-making circuit with proteins, de novo protein heterodimers and engineered proteases. By creating protein pairs that bind together ...

Biophysicists have elucidated why unexpected structures can sometimes arise during protein design. Artificially designed proteins are usually based on building blocks that obey strict rules of ...

New findings show that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like ...

Moreover, each step in the flow of information from DNA to RNA to protein provides the cell with a potential control point for self-regulating its functions by adjusting the amount and type of ...

Instead, we think this circuit causes the craving of highly rewarding ... Conversely, when the researchers injected a virus engineered to produce a protein that dampens the cells' activity ...