Hong Kong-based Insilico Medicine has announced positive results from two Phase I studies of ISM5411 (NCT06012578), a novel gut-restricted and prolyl hydroxylase domain (PHD)-specific inhibitor ...

In the presence of oxygen, active hypoxia-inducible factor (HIF) hydroxylases (that is, prolyl hydroxylase domains, PHDs, and factor inhibiting HIF, FIH) downregulate and inactivate HIF1α subunits.

Stone and Meister discovered that vitamin C is used as a co-substrate by peptidyl-prolyl hydroxylase, an enzyme that catalyzes the selective modification of proline to hydroxyproline. This ...