Changing the structure of PrP alters the incubation ... The first is that the active component in prions is an abnormal protein called prion protein (abbreviated PrP). Normal animal cells make ...

Almost two decades have passed since Stanley Prusiner proposed that the transmissible agent causing spongiform encephalopathies consists of a misfolded protein — but the biology of prion ...

A recent paper reported the in vitro generation of new prion strains, supporting the idea that 'strain-ness' is encoded in the protein structure itself. This lays the groundwork for a ...

View Full Profile. Learn about our Editorial Policies. Bacterial proteins capable of acting like prions could help the microbes to adapt to environmental changes. One of the genes liberated from Rho ...

prion protein (PrP), and Huntingtin (HTT). The goal is to develop a deeper understanding of each protein’s normal structure/function and how these are altered in neurodegenerative disease by genetic ...

Intrinsically disordered proteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly ... to ...

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a study published in Neuron, ...

The intrinsically disordered proteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly ... to Machado-Joseph disease), and the prion protein (implicated in Creutzfeldt ...