A prime example of proteins that catalyze their own conformational change into the toxic form is the prion proteins ... to the prevention of protein misfolding. Despite chaperone actions, some ...

A new study reveals a possible protein misfolding mechanism that may resolve a long-standing mystery of why certain proteins refold into unexpected patterns. Proteins are long molecules that must fold ...

They can be genetic, sporadic—without known cause—or acquired, in which exposure to abnormal prion protein induces misfolding of the host’s own normal prion proteins. While prion disorders like ...

also called Creutzfeldt-Jakob disease (CJD), results from the misfolding of a normal prion protein—an essential protein present in everyone. The misfolded form of the protein, the cause of CJD ...

The video shows the mechanism by which the aggregated and infectious form of the prion protein (red ... and itself promotes the misfolding of another normal protein nearby. Once they reach ...

A new study has described a potential mechanism that could help explain why some proteins refold in a different pattern than expected. The research showed that a type of misfolding, called non ...

Saborio, G.P. et al. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 411, 810–813 (2001).

The US Centers for Disease Control and Prevention defines two types of CJD: classical, which generally arises through spontaneous protein misfolding in the brain, and variant CJD (vCJD), which is ...