Misfolded, prion-like proteins drive the progression of tauopathies ... role of water around the protein surface that guides the misfolding process. A mutation commonly used to model tau-related ...

Tauopathies are neurodegenerative diseases driven by tau protein misfolding and subsequently accumulating into dense, ordered fibrils. These tauopathies are prion-like, meaning that misfolded tau ...

They can be genetic, sporadic—without known cause—or acquired, in which exposure to abnormal prion protein induces misfolding of the host’s own normal prion proteins. While prion disorders like ...

Prion diseases, Alzheimer’s disease ... are all part of the landscape of neurodegenerative diseases linked to protein misfolding. Each disease involves its own unique misfolded protein or ...

As the disease progresses, the brain takes on a sponge-like perforated structure and shows protein deposits. "The disease is triggered by the misfolding of the cellular prion protein, PrP for ...

Misfolding of the prion protein triggers prion diseases such as Creutzfeldt-Jakob disease. All research findings to date indicate that the misfolded prion protein acquires toxic activity.

Misfolded, prion-like proteins drive the progression of tauopathies ... role of water around the protein surface that guides the misfolding process. A mutation commonly used to model tau-related ...