Scientists are exploring the key proteins and metabolic pathways in Plasmodium falciparum to develop new drugs to prevent malaria. Pink block arrows indicate the steps inhibited by antimalarial ...

Malaria, caused by a parasite transmitted to humans through an infected mosquito's bite, is a leading cause of illness and death worldwide.

Despite decades of efforts focused on mosquito eradication, drug therapies, and vaccines, malaria remains hard to beat, especially in Africa.

The disease is caused by five species of Plasmodium parasites, with Plasmodium falciparum responsible for the most severe cases. In 2024 alone, malaria accounted for more than 250 million cases ...