Cancer-associated fibroblasts (CAFs) comprise the majority of the tumor bulk of pancreatic ductal adenocarcinomas (PDACs). Current efforts to eradicate these tumors focus predominantly on ...

The results give a new direction for pancreatic cancer researchers by providing valuable insights into fibroblast biology during pancreatic cancer progression. Fibroblasts and cancer-associated ...

Cancer-associated fibroblasts (CAFs ... deletion of the protein suppressed the ability of pancreatic fibroblast cells to invade when co-cultured with pancreatic cancer cells, suggesting that ...

The findings are published in Cancer Research in an article titled, “Fibroblasts in the aged pancreas drive pancreatic cancer progression.” “Pancreatic cancer is more prevalent in older ...

This new data, published recently in Nature Communications, is the first to show the cellular origin of normal pancreatic fibroblasts and cancer-associated fibroblasts (CAFs) that influence tumor ...

Deaths from pancreatic ductal adenocarcinoma ... between immune cells called B and T cells and specialized cancer-associated fibroblasts that promote inflammation. The researchers then used ...

Cancer-associated fibroblasts (CAFs ... including reports that found levels of SAA proteins in pancreatic ductal adenocarcinoma and non-small cell lung cancer were elevated in cases of liver ...

Researchers at Umeå University, Sweden, have discovered a previously unknown type of connective tissue cells that surround cancer cells in pancreatic tumors. The newly discovered cells counteract ...

Autophagy of cancer cells has been frequently observed during radiotherapy. In addition, pancreatic cancer-associated fibroblasts can compromise the radiotherapeutic effect by promoting the autophagy ...

“The problem with pancreatic cancer is that we often catch it too late,” said Jared Fischer, a scientist with OHSU Knight Cancer Institute’s Cancer Early Detection Advanced Research Center ...