and osteoclasts, which are responsible for bone resorption. Until now, it has not been understood how these cells function in the low-oxygen microenvironment of bone. Researchers at the Max Planck ...

Bone is constantly being remodeled through a process of resorption, in which old bone tissue is removed by osteoclasts, and formation, in which the old bone tissue is replaced with new tissue ...

A new study in mice shows how the small GTPase Cdc42 influences bone modeling and remodeling—it modulates both the formation and function of osteoclasts, and is involved in the downstream ...

Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel increases in serious and potentially fatal comorbidities, particularly type 2 ...

Patients with systemic sclerosis and calcinosis cutis may have a higher tendency for bone-resorbing cell activity, suggesting ...

Aging Health. 2012;8(5):471-477. Osteoporosis associated with chronic glucocorticoid therapy appears to be an important medical problem, which may often be underestimated. Glucocorticosteroids ...