Understand why menopause causes bone density loss in women. Learn the hormonal changes responsible and effective strategies ...

The osteoclast–bone interface creates a unique extracellular microenvironment, ideal for bone resorption. The lysosome-rich vacuolar zone (black arrow), composed of acidified vesicles containing ...

A recent study involving 684 Chinese adults has uncovered a significant connection between gut microbiota, aging, and bone ...

The findings revealed that proteins named Rab32 and Rab38 play pivotal roles in bone resorption in osteoclast, cell specialized in the process. These proteins are also crucial for pigmentation of ...

Researchers have developed a novel compound that could be useful for treating bone-destructive diseases. Their study ...

These conditions often result from the dysregulation of osteoclasts—specialized ... for building new bone—suggesting a highly targeted effect on bone resorption without compromising bone ...

Their research has found that mechanosensitive protein polycystin-1 (PC1, encoded by Pkd1) plays an important role in osteoclast-mediated bone resorption. The authors conducted a cohort study of ...

Excessive osteoclast activity can lead to increased bone resorption, which contributes to osteoporosis. The findings revealed that iSN40 completely inhibits the differentiation of osteoclast ...

Bone is resorbed by specialized cell called osteoclast, and several substances are secreted out to the pits where osteoclast attaches to bones and resorption occurs, like acids (H +) and degrading ...