This seems to cause defects that affect 18S rRNA maturation and 40S-ribosome-subunit production 56, which indicates that impairment of functions in the nucleolus is responsible for the disease ...

There are three structures in the nucleolus which perform various functions in ribosome production: the granular component (pre ribosome assembly) fibrillar center (rRNA transcription) and the ...

of the nucleolus. The FC is known to be involved in the production of ribosomal RNA, a key component of ribosomes, the cell complex responsible for building all cellular proteins. However ...

The nucleolus is a special part of the cell nucleus that houses ribosomal DNA, and where ribosomal RNA production and ribosome assembly largely takes place. Nucleoli can vary greatly in appearance ...

Ph.D. The nucleolus is a special part of the cell nucleus that houses ribosomal DNA, and where ribosomal RNA production and ribosome assembly largely takes place. Nucleoli can vary greatly in ...

tiered spatial organization of the nucleolus is essential to ribosome production. But the MDIBL scientists observed that while removing a key protein domain of NUCL-1 in transgenic C. elegans ...

The study identifies the nucleolus as a target of inhibitors ... Combination of SILAC quantitative proteomics, rRNA production/processing and ribosome profiling show that in contrast to the ...

This leads to ribosome production arrest and a potentially alternative way p14 ARF elicits its tumor suppressor function. “Upon overexpression, p14 ARF can go to the nucleolus and block ...

The nucleolus isolates the rDNA which encodes the RNA portions of the ribosomes, the protein-building machinery. The rDNA is one of the most fragile parts of the genome, due to its repetitive ...