and consequently defects in regulation of the actin cytoskeleton lead to various diseases including cancer progression, as well as neurological and immunological disorders. Our group uses a wide range ...

In our lab, we aim to elucidate the interplay of clathrin structures with the actin cytoskeleton and cellular adhesions. This work enables us to apply our findings to understand disease processes and ...

Some proteins in human cells that are implicated in cancer also have causal roles in neurodevelopmental disorders, raising ...

At UChicago, McCord researches a protein called actin, which is involved in many important ... Meanwhile, McCord will head to Cincinnati Children’s Hospital as a rare neurodevelopmental disease ...

More information: Holly Merta et al, Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration, Cell Reports (2025). DOI: 10.1016/j.celrep ...