Deficiencies in immunoregulation (such as dysfunctional NK cells or the absence of hemolytic complement) make NOD mice congenic for additional immunodeficiency genes (scid and rag ) ideal hosts ...

Using a xenogeneic model of GvHD in NOD/SCID/γc− (NSG) mice, we showed that weekly administration of IVIG significantly reduced the incidence and associated mortality of GvHD to a degree ...