The recent discovery that the nuclear transcription factor forkhead box P3 (Foxp3) appeared necessary and sufficient for Treg development ... T cells undergoing differentiation in the thymus ...

He uses mouse models to study the thymus, the organ in which specialized immune cells called T cells mature. His goal is to apply his findings to develop new therapies to promote immunity in cancer ...

The findings are published in the journal Cell Reports. "Studying the development ... built on mouse models applies to human physiology." The team discovered that innate-like T cells mature ...

In mouse model experiments, increasing FGF21 preserved both the size and function of the thymus, allowing for greater T-cell variation. Inside the labyrinth: How thymic structures rebuild Stromal ...

"Studying the development of the ... how much our knowledge built on mouse models applies to human physiology." The team discovered that innate-like T cells mature differently in humans than ...

T-cell acute lymphoblastic leukaemia (T-ALL) is a paediatric leukaemia associated with distinct clinical and biological characteristics. Historically linked with a poor prognosis, T-ALL represents ...