The recent discovery that the nuclear transcription factor forkhead box P3 (Foxp3) appeared necessary and sufficient for Treg development ... T cells undergoing differentiation in the thymus ...

In thymic epithelial cells, the research team upregulated a transcription factor called Forkhead box N1 (FOXN1), which had previously been implicated in age-related thymus shrinkage. Consequently, the ...

A fine balance is needed for T reg cells to enable immune responses to pathogens without triggering autoimmunity. Data now show that thymus-derived ... authors use LCMV mouse infection model ...

The findings are published in the journal Cell Reports. "Studying the development ... built on mouse models applies to human physiology." The team discovered that innate-like T cells mature ...

He uses mouse models to study the thymus, the organ in which specialized immune cells called T cells mature. His goal is to apply his findings to develop new therapies to promote immunity in cancer ...