The nanoparticle is made of a biodegradable polymer that is loaded with two prodrugs that target cancer cells' mitochondrial DNA, according to a May 6 article on the university's website.

By honing those polymers further, Dhar’s team developed a nanoparticle that can cross both the blood-brain barrier and the outer membrane of mitochondria. “There have been a lot of ups and ...

People often refer to mitochondria as the powerhouses of the cell. Their main function is to generate the energy necessary to power cells, but they are also involved in cell signaling and death.

By honing those polymers further, Dhar’s team developed a nanoparticle that can cross both the blood-brain barrier and the outer membrane of mitochondria. “There have been a lot of ups and ...

Lipid droplets act as energy stores in the cell, while mitochondria metabolize this energy. The analysis of the images showed: The nanoparticles accumulate preferentially in a subset of the cell ...

It has been widely used to target various small molecules and nanoparticles to mitochondria for therapeutic purposes. Dequalinium (DQA) self-assembles into DQAsomes, which preferentially ...

Although zinc oxide nanoparticles (ZnONPs ... autophagic flux resulted in the accumulation of damaged mitochondria, which could generate excessive ROS to cause cell death. We further demonstrated ...