As a result, ROS from overactive mitochondria are frequently cited as a source of DNA damage. Despite this longstanding belief, few studies have explicitly demonstrated this linkage. Tobias Dansen, a ...

ATP-production is essential for vesicle docking, fusion and endocytosis. Mitochondrial pathology and some treatments affect the mitochondrial membrane potential. Disrupting the MMP results in more ...

known today as mitochondrial DNA (mtDNA). Today mtDNA produces 13 key mitochondrial proteins. As mitochondria age, they change shape and become less active. Eventually they fail and release mtDNA.

humans who lived elsewhere in the world at the time of mitochondrial Eve were completely ... confirmed by recent studies using more sensitive DNA markers (Templeton, 1997). Clearly, far more ...

Damage to the genetic material of mitochondria – the mitochondrial DNA or mtDNA for short – can lead to diseases such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis (ALS), cardiovascular ...

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the ...

Scientists say they have discovered how a group of proteins linked to Parkinson's disease and amyotrophic lateral sclerosis act as 'guardians' of mitochondria, small organelles, or subunits, within a ...

The POLG gene regulates the production of DNA polymerase gamma, an enzyme that copies mitochondrial DNA. Without it, the ...

The POLG gene regulates the production of DNA polymerase gamma, an enzyme that copies mitochondrial DNA. Without it, the mitochondria cannot function normally and, as a result, fail to provide the ...

When the mechanisms that replicate or repair mitochondrial DNA (mtDNA) fail, it can cause a wide range of syndromes for which there are few to zero existing treatment options. One of the causes of ...