Two microtubule-associated proteins (MAPs), NuMA and TPX2, have been identified as potential downstream effectors of Ran-GTP in microtubule assembly in these extracts 16,17,18.

Increased mitotic microtubule plus-end assembly rates influence CIN. To investigate the relationship between increased microtubule assembly rates and CIN we restored normal microtubule assembly ...

"Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly," by Hong-Wei Wang and Eva Nogales, appears in the 16 June 2005 issue of Nature.

Researchers led by Dr. Jens Lüders at IRB Barcelona have discovered a key role played by the ch-TOG protein in the initiation of microtubule assembly during the interphase stage of the cell cycle ...

Berkeley Lab researchers have produced images of microtubule assembly and disassembly at the unprecedented resolution of 5 angstroms, providing new insight into the success of the anti-cancer drug ...

Elevated TPX2 levels lead to both aberrant microtubule assembly in cells and poor outcomes in cancer patients. But how TPX2 works with augmin and γ-TuRC to mediate branching microtubule ...

Brownian dynamics-kinetic Monte Carlo simulations show that Ase1 and Cls1 activity are sufficient for initial bipolar spindle formation. We conclude that pushing forces generated by microtubule ...

Microtubule Assembly. Process Component Function Recommended Products; Microtubule nucleation: γ-tubulin: Forms part of the microtubule organizing centers (MTOCs), and facilitates tubulin dimer ...

By using cryo-electron microscopy, the team demonstrated how CDK5RAP2 binds to γTuRC, allowing it to adopt a functional shape necessary for microtubule nucleation, crucial for cell structure and ...

Magic-angle-spinning NMR used to probe protein/microtubule assembly at atomic scale. by University of Delaware. An example of one MAS NMR spectrum. This is ...

Paclitaxel binds to microtubule polymer with high affinity, ... Conde, C, Caceres, A. Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci 2009;10:319-332.