The guanosine tri-phosphatase Ran stimulates assembly of microtubule spindles. However, it is not known what aspects of the microtubule cytoskeleton are subject to regulation by Ran in mitosis.

"Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly," by Hong-Wei Wang and Eva Nogales, appears in the 16 June 2005 issue of Nature.

Researchers led by Dr. Jens Lüders at IRB Barcelona have discovered a key role played by the ch-TOG protein in the initiation of microtubule assembly during the interphase stage of the cell cycle ...

Berkeley Lab researchers have produced images of microtubule assembly and disassembly at the unprecedented resolution of 5 angstroms, providing new insight into the success of the anti-cancer drug ...

Structural basis of tubulin recruitment and assembly by microtubule polymerases with Tumor Overexpressed Gene (TOG) domain arrays. eLife , 2018; 7 DOI: 10.7554/eLife.38922 Cite This Page : ...

By using cryo-electron microscopy, the team demonstrated how CDK5RAP2 binds to γTuRC, allowing it to adopt a functional shape necessary for microtubule nucleation, crucial for cell structure and ...

Paclitaxel binds to microtubule polymer with high affinity, ... Conde, C, Caceres, A. Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci 2009;10:319-332.

An example of one MAS NMR spectrum. This is used to identify atoms in the molecule and, ultimately, for calculating their 3-D structures.

Inside every cell, a network of tiny filaments, called the microtubule cytoskeleton, helps maintain the cell's shape, allows it to divide, and transports vital materials from one part of the cell ...

More information: Maksim Kalutskii et al, Microtubule dynamics are defined by conformations and stability of clustered protofilaments, Proceedings of the National Academy of Sciences (2025). DOI ...

Many fundamental processes of life, and their synthetic counterparts in nanotechnology, are based on the autonomous assembly of individual particles into complex patterns. LMU physicist Professor ...