Bone-dissolving cells called osteoclasts are derived from a type of immune cells called macrophages. They are necessary for the maintenance and renewal of bones. But the intracellular mechanisms ...

Osteoclasts are specialized, ... They are formed under the presence of macrophage colony-stimulating factor and the receptor activator of the NF-KB ligand.

Macrophage inflammatory protein 1α also appears to be a key regulator of bone destruction in myeloma. 53,54 Macrophage inflammatory protein 1α is a potent inducer of osteoclast formation in ...

Researchers from Tokyo Medical and Dental University (TMDU) found that light-mediated activation of RANK in macrophages induces them to differentiate into mature osteoclasts. This optogenetics ...

Osteoclasts, on the other hand, develop from the development of macrophages or monocytes which are two types of immune cells. Suppressing osteoclast differentiation could thus be used as a ...

Osteoclasts arise from the differentiation of macrophages or monocytes, which are types of immune cells. Suppressing osteoclast differentiation can, therefore, serve as a therapeutic strategy to ...

Then the researchers developed a model that used patient-varying kinase signals collected from the macrophages or osteoclasts to predict patient-specific activity of four cathepsins: K, L, S and V.

Bone-dissolving cells called osteoclasts are derived from a type of immune cells called macrophages. They are necessary for the maintenance and renewal of bones. But the intracellular mechanisms ...

Now, a team of researchers in China and Australia has shown that SARS-CoV-2 infection can affect bone marrow macrophage (BMM)-to-osteoclast differentiation, which may impact the skeletal system.

Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium urate crystals, or MSUc; CPPD disease, another inflammatory joint disease ...