He labeled proteins and followed them in their journey through the cell. He observed that the lysosomes described by de Duve contained fragments of the labeled proteins, and concluded that ...

Fats and other cellular materials reach the lysosome through three main pathways: endocytosis, phagocytosis, and autophagy. In endocytosis, the cell takes in materials from outside by wrapping ...

The Lysosome This small particle acts as the digestive tract of the living cell. Its enzymes dissolve the substances ingested by the cell and under certain circumstances can dissolve the cell itself ...

Research had already established one way that cells repair leaky lysosomes. Previously, a collection of proteins known as the ESCRT machinery was found to patch up holes in the organelles’ membranes.

Trafficking occurs in both directions; the forward direction takes vesicles from the site of synthesis to the Golgi apparatus and next to a cell's lysosomes or plasma membrane. Vesicles that have ...

A study reveals how glutamate drives tau accumulation in Alzheimer’s and related disorders. Researchers found that blocking the gene KCTD20 activates lysosomes, helping clear toxic tau proteins in lab ...

Feng Wei at the Institute of Biophysics, Chinese Academy of Sciences, has made significant strides in understanding the BORC complex, a key player in lysosome transport and localization.

The biotech is focusing on precision, small-molecule medicines that work via a process known as cellular clearance by activating the lysosome, sometimes referred to as the cell’s recycling and ...

If you care about Alzheimer’s disease, please read studies about vitamin D deficiency linked to Alzheimer’s and dementia, and ...

This nanoplatform can actively target tumor regions and accumulate in the lysosomes of tumor cells. Upon light irradiation, it can induce lysosomal dysfunction by generating a large amount of ...