The tissue transglutaminase IgA test is the most sensitive and effective method of celiac disease testing. It shows positive results in almost 98% of people with celiac disease who eat gluten.

Celiac disease affects 0.6 to 1.0% of the population worldwide, 2,3 with wide regional differences in Europe (e.g., the prevalence is 0.3% in Germany and 2.4% in Finland) for reasons that are ...

A patient should be screened with an IgA tissue transglutaminase antibody and a total IgA level. In those patients with a low IgA level, an IgG ttg and IgG antigliadin antibody should be tested. In ...

Total serum IgA: This checks for IgA deficiency, a condition in 2% to 3% of those with celiac disease that may lead to a false negative result in tTG-IgA or EMA tests.

In addition, transglutaminase IgA is very low in children in whom only lymphocytic enteritis is observed. On the other hand, Marsh I can represent >50% of cases in adults.

In adults, the most common symptoms of celiac disease are stomach problems, like gas and diarrhea. A tissue transglutaminase IgA test, or tTg-IgA test, is an effective method used in the diagnosis ...

For adults with suspected celiac disease and no IgA deficiency, ... Limitations include a lack of data on IgA-deficient participants, a low number of participants in some subgroup analyses, ...

Reporting online in Lancet Gastroenterology and Hepatology, Ciacci's group said the positive predictive value of the blood test was 95.9% (95% CI 92-99.8) and the negative predictive value was 90. ...

In an evaluation of 1,000 consecutive patients screened for celiac disease, TTG IgA was determined to be highly sensitive (100%) for celiac disease in those with partial IgA deficiency. In ...

If there is a low pretest probability, testing can begin with IgA and TTA Ab testing. Note that about one in 500 people in the U.S. are IgA deficient, which could lead to a falsely low TTA Ab test.

IgA nephropathy is an autoimmune disease of the kidneys. It's associated with several health conditions, such as lupus, celiac disease, and kidney failure.