Loss-of-function mutations in ANGPTL3 are associated ... of plasma lipoprotein levels by inhibiting the enzyme lipoprotein lipase. Here, I review the role of ANGPTL3 in lipoprotein metabolism.

Postheparin lipoprotein lipase was partially purified by the method of Nikkilä 24 and the specific activity was expressed in microequivalents of free fatty acids released by 1 gm. of protein ...

Sometimes FCS is called lipoprotein lipase deficiency. When you have FCS, fatty droplets called chylomicrons build up in the plasma of your bloodstream. Chylomicrons help move triglycerides to ...

Lipoprotein particle metabolism can occur via ... and free fatty acids through various processes, including gastric lipase, bile emulsification and pancreatic lipase. Similarly, cholesterol ...

Gaudet noted that loss-of-function mutations in and pharmacologic ... ANGPTL8 forms a complex with ANGPTL3 that inhibits lipoprotein lipase 100-fold more potently than ANGPTL3 alone, and ...

During the first 18 months after treatment with ali-pogene tiparvovec, a gene therapy recently approved in Europe to treat lipoprotein lipase deficiency (LPLD), the first patient to receive the ...

New Rochelle, NY, May 1, 2018--During the first 18 months after treatment with ali-pogene tiparvovec, a gene therapy recently approved in Europe to treat lipoprotein lipase deficiency (LPLD), the ...

Amsterdam Molecular Therapeutics (AMT) and Progenika Biopharma are to jointly develop a diagnostic for lipoprotein lipase deficiency (LPLD). The LPLchip test will be based on Progenika’s DNA ...

The article "Gene Therapy in Lipoprotein Lipase Deficiency (LPLD): Case Report on the First Patient Treated with Alipogene Tiparvovec under Daily Practice Conditions" was coauthored by Ursula ...