Primary and secondary antibodies share a common structure ... the two heavy chains together and each heavy chain to a light chain. The specific structure and combination of these chains allow ...

The antibody library of the platform was established in a rigorous way. To be specific, 2 common light chains were selected through alignment and screening of 1800+ light chain sequences ...

will react with epitopes on both heavy and light chains, so they will react with other isotypes of primary antibody or different subtypes of IgG. Secondary antibodies that specify a specific isotype ...

Hapten-binding proteins (4.5 μg) were fractionated under reducing conditions and immunoblotted with Ig-κ light chain-specific antibody (The Binding Site), mouse IgE-specific antibody (Pharmingen ...

B cells of the immune system become plasma cells when activated by the binding of a specific antigen on its antibody surfaces ... the ends of the heavy and light chains on both sides.

amyloidosis is characterized by deposition of amyloid fibrils of light chains produced by clonal CD38+ plasma cells. Daratumumab, a human CD38-targeting antibody, may improve outcomes for this ...

Secondary and exploratory objectives included ... NEOD001, a humanized form of murine monoclonal antibody 2A4, binds to an epitope unique to the misfolded light chain protein. The cryptic light chain ...