GPR6 is an orphan G protein-coupled receptor primarily expressed in the ... a lipid-like molecule occupying the orthosteric ligand-binding pocket. A cryo-EM structure of the fully active GPR6 ...
The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?
G Protein-Coupled Receptors (GPCRs) in advancing GPCR-targeted therapies, including the use of agonists, antagonists, biased ...