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To mimic protein aggregation in the cataractous lens, six known cataract-causing mutant crystallin proteins were expressed in human lens progenitor cells, human lens epithelial line B-3 (HLEB-3 ...
However, the precise mechanisms by which lens proteins both prevent aggregation and maintain lens transparency are largely unknown. Lanosterol is an amphipathic molecule enriched in the lens.
The mechanism behind how proteins that are critical for the transparency of the eye lens are properly sorted and localized in membrane bilayers has been highlighted in new research.
New research reveals how proteins that are critical for the transparency of the eye lens are properly sorted and localized in membrane bilayers. The study analyzes how interactions between lipid ...
See ocumetrics bionic lens from a couple months back, but as far as I can tell, the procedure & replacement lens sounds identical to existing cataract surgery. pmshah July 24, 2015 01:33 AM ...
A molecular dance of sorts between two proteins in the eye lens can create either perfect vision or cloudy cataracts. By applying physics and biology to the complexities of vision, scientists ...
Protein in lens cannot be replaced or rebuilt. There may be many causes behind this clouding of the lens. But one truth is that these lens proteins are formed in the embryo and are not replaced ever.
Aggregation can occur across the process of making a therapeutic protein. Upstream, cell growth and protein stability depend on many factors and conditions, including aeration, agitation, antifoam ...
By studying protein accumulation in the nematode worm C. elegans Dr Della David and her team found that even when the typical protein quality control mechanisms were disrupted, there were lower levels ...