A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene ...

Researchers find that certain antioxidant enzymes, called selenoproteins, significantly contribute to fighting cell aging. The team used a gene knockout mouse model to help them study the effects of ...

For those frustrated by the brute force of knockout mice when studying gene function, in vivo RNA interference (RNAi) would seem to have come to the rescue. In theory, in vivo RNAi promises a more ...

It’s a new way to create “bi-paternal” mice that can survive to adulthood—but human applications are still a long way off.

View Full Profile. Learn about our Editorial Policies. When the researchers monitored the metabolic rates of the Klf15 knockout mice they observed that these mice burned more energy compared to ...

Myocardial fibrosis is a key process for heart failure development that may lead to severe phenotypes, including cardiac arrest or sudden death. Vasorin (VASN) is a protein with high expression in the ...

They followed by isolating EVs from normal mice and knockout mice lacking the gene that encodes the BK potassium channel, and found the cargo in EVs from the knockout mice were very different in ...

They followed by isolating EVs from normal mice and knockout mice lacking the gene that encodes the BK potassium channel, and found the cargo in EVs from the knockout mice were very different in ...