Autoinhibition in the absence of cargo In the absence of cargo, kinesin activity must be tightly controlled to prevent futile ATP hydrolysis and congestion of microtubule tracks. Recent work has ...

It literally walks along the surface of the microtubules, lurching forward step by step. Kinesin gets its energy from a molecule called adenosine triphosphate (ATP). Every step forward requires ...

Kinesin is a vital player in transporting cargo, like neurotransmitter-filled vesicles, along the microtubule rails that span our cells. Fueled by the splitting of ATP, kinesin moves by “stepping” ...

answered a long-standing question of head coordination in kinesin. They found that fluorescent ADP produced by the hydrolysis of fluorescently labeled ATP nucleotides is not immediately released ...

and cell biological mechanisms of the cytoskeletal molecular motors dynein and kinesin. The group studies these molecular machines in two ways: 1) at the level of individual motors to better ...