First, they took apart the anti-PD1 antibody into its various V, D, and J gene segments and introduced more junctional diversity near the most variable portion of the antibody—the area of the ...

In line with the role of T cells as critical mediators of the adaptive immune response, recombinational and junctional diversity of the T cell receptor makes each T cell almost entirely unique.

Could it be, they asked, that this identical ‘microhomology’ region determined the repair process to limit junctional diversity at the sealed breakpoint? Microhomology sequences offer the possibility ...