Stem-cell derived organoids provide the perfect mixture of cells to rebuild damaged intestines.

In a recent study, FMI researchers have shed light on how intestinal organoids form crypts, the pockets that house stem cells for gut ... "As the organoid's lumen volume decreases, the tissue ...

Caption A single human intestinal organoid, or HIO -- a hollow ball of cells grown from human embryonic stem cells and coaxed to become gut-lining cells. Scientists can use it to study basic gut ...

The use of the heterogeneous and ill-defined 3D cell culture platform Matrigel has facilitated organoid culture with impressive ... and bond formation to study how intestinal stem cell colonies ...

Intestinal organoids ... and reproducibility challenges in organoid systems. In a recently published Science paper, 1 his team described how they developed a biomaterial tissue scaffold that allows ...

Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and ...

We’re particularly interested in enteroendocrine cells — cells found in the lining of the small intestine and throughout the intestinal ... lab in the form of an organoid.

By comparing young and aged mouse intestinal tissues, the researchers uncovered critical insights into the interplay between these signaling pathways in supporting stem cell maintenance over time.

Organoids are made to model human organs and are promising for research and therapy, but there are limitations in their growth and function. A recent study found that placenta-derived IL1 under ...

Desai uses human pluripotent stem cells to grow pancreatic ductal and acini-like cells as mini ‘organs’ called – Organoids. This organoid technology provides us with an invaluable tool to investigate ...

In cystic fibrosis, researchers have used CRISPR HDR-mediated knock-in to correct mutations in the CFTR gene in airway stem cells ... for drug development. Organoid and organ-on-a-chip models ...