Researchers at the Francis Crick Institute have shown that the Cryptosporidium parasite exports a protein into infected ...

In a recent study, FMI researchers have shed light on how intestinal organoids form crypts, the pockets that house stem cells for gut ... "As the organoid's lumen volume decreases, the tissue ...

Advances in CRISPR ... cells into induced pluripotent stem cells (iPSCs) and other advances in tissue engineering have enabled scientists to grow a range of different tissues, including mini guts, ...

Numerous studies have suggested the cultivation of cells derived from intestinal organoids as two-dimensional (2D) monolayers ...

Caption A single human intestinal organoid, or HIO -- a hollow ball of cells grown from human embryonic stem cells and coaxed to become gut-lining cells. Scientists can use it to study basic gut ...

The use of the heterogeneous and ill-defined 3D cell culture platform Matrigel has facilitated organoid culture with impressive ... and bond formation to study how intestinal stem cell colonies ...

Intestinal organoids ... and reproducibility challenges in organoid systems. In a recently published Science paper, 1 his team described how they developed a biomaterial tissue scaffold that allows ...

began with a genome-wide genetic screen based on CRISPR interference (CRISPRi) that systemically reduces the expression of every single gene in the genome of a pluripotent stem cell (PSC ...

He works in collaboration with the lab of Matthias Zilbauer at the Cambridge Stem Cell Institute, where he completed his ... During his PhD, Dennison gained expertise in the intestinal epithelium and ...