a protein complex found within the inner mitochondrial membrane that the Chandel laboratory previously demonstrated supports other immune responses. Whether the mitochondrial respiratory chain is ...

The outer membrane of mitochondria and chloroplasts has pores that allow small molecules to pass easily. The inner membrane is loaded with the proteins that make up the electron transport chain ...

(B) Scheme of the protein complexes that form the ETS, showing the mitochondrial membranes in blue and red; NADH dehydrogenase in light green; succinate dehydrogenase in dark green; the complex ...

One innovative approach to tackling cancer involves targeting the inner mitochondrial membrane (IMM). Maintaining its electrical potential gradient, known as ∆Ψm, is critical for mitochondrial ...

One key target for such work is the decline in the organelle’s membrane potential: the difference in electrical charge between each side of the inner mitochondrial membrane that is essential for ...

Elamipretide is a cell-permeable peptide compound designed to improve mitochondrial function by targeting the inner mitochondrial membrane where it binds reversibly to cardiolipin. We continue to work ...

A sole Pi exporter has been identified – SLC53A1. The mitochondrial carrier SLC25A2 transports Pi across the mitochondrial inner membrane to support ATP synthesis. Other transporter families, such as ...